Master key paralyzes the corona virus, camouflage through mutation no longer works effectively according to the University of British Columbia & More Latest News Here


The unchangeable parts of the spike protein are stained red. Photo: Sriram Subramaniam, University of British Columbia

Master key paralyzes the corona virus, camouflage through mutation no longer works effectively according to the University of British Columbia

Vancouver, Boston, August 23, 2022

Part of the spike protein with which the #corona #virus is equipped is the same for all variants. This was discovered by an international research team led by Sriram Subramaniam from the University of British Columbia. The experts have also found an antibody fragment that could block this part of the spike protein, called the epitope, so that it can no longer attack the host cell, ie protect it from infection. It would be comparable to the master key in a system that locks many different locks that all have something in common.

Virus can no longer dock

The researchers used what is known as cryo electron microscopy to find what the SARS CoV 2 variants alpha, beta, gamma, delta, kappa, epsilon and omicron have in common. In this method, deep-frozen organic samples are made visible using electron microscopy. The antibody fragment VH Ab6 blocks the epitope and thus prevents the virus from attaching itself to human cells.

“Antibodies attach themselves to a virus in a very specific way, like a key being inserted into a lock. But when the virus mutates, the key no longer fits. That’s why we looked for master keys – antibodies that continue to neutralize the virus even after extensive mutations,” says Subramaniam. So far it has only been possible to demonstrate the principle of blocking. Actually working #medicines that build on this have yet to be developed.

Comparable results in Boston

A team from Harvard Medical School and Boston Children’s Hospital also shows that Subramaniam’s researchers are on the right track. Your antibody candidate has neutralized all current SARS CoV 2 variants in animal experiments. After researchers in Boston genetically engineered mice so that they would elicit human-like #immune responses to SARS CoV 2, the researchers exposed the #animals to parts of the virus and recorded nine different groupings of antibodies. A specific #antibody, called SP1 77, was shown to be effective in #blocking #infection by all known variants.

Master key paralyzes the corona virus, camouflage through mutation no longer works effectively according to the University of British Columbia
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